References and Information

The references below provide information on the assays used to generate the data on this site and the use of the data to build ADME / PBPK models.

1. Evaluation of an Integrated in vitro-in vivo PBPK Model to Provide Estimates of Human Bioavailability
2. Assessment of the Physiologically-Based iDEA™ Predictive Model
3. Validation of iDEA™
4. The Implementation of the iDEA™ Model in Pfizer's Drug Discovery Process
5. Cell Viability of Human  Cryopreserved Primary Hepatocytes
6. Development and Validation of a Miniaturized Solubility Method
7. Estimation of Michaelis-Menten Parameters Using Early Discovery Metabolic Turnover Data
8. Effect of Percoll Centrifugation on Cell Viability and Enzyme Activities in Cryopreserved Human Hepatocytes
9. Impact of Experimental Conditions on In Vitro Permeability - 1. Correlations in inter-Laboratory Caco-2
10. Impact of Experimental Conditions on In Vitro Permeability - 4 Effect of Fasted State Simulated Intestinal FLuid (FaSSIF) in Caco-2 and Rabbit Intestine (abstract only)
11. A Case Study: In Vitro Profiling of a Diversified Set of Compounds for Validation Testing Using the iDEA™ Predictive Model
12. Modulation of Non-Specific Binding in Ultrafiltration Protein Binding Studies
13. The Construction of a Representative Human Cryopreserved Hepatocyte Pool for Metabolism Study  
14. The Effect of DMSO on the Absorption and Metabolism Screening of Drug Discovery Process
15. The Impact of Human Cryopreserved Hepatocyte Pool Donor Substitutions on Predictive Metabolism Performance