Caco-2 Facts

Caco-2 Compound List

This is a partial list of compounds that are in the Caco-2 dataset.  The compounds that are not included here were taken from combinatorial libraries and are unique non-drug structures.

 

Caco-2 Assay Compounds (partial list)

aminopyrine
abecarnil
acebutolol
acetaminophen
acetanilide
acetazolamide
acyclovir
albendazole
albuterol

allopurinol
alprazolam
alprenolol
amantadine
amiloride
 
amitriptyline
amoxicillin
ampicillin
amprenavir 
 
antipyrine
aspirin
astemizole
atenolol
azathioprine
azithromycin
aztreonam
baclofen
bamethane
bendroflumethiazide
benzoic acid
bepridil
betaxolol
bretylium 
bromocriptine
budesonide
budesonide
buflomedil
bumetanide
bupropion
buspirone
caffeine
camptothecin
 
carbamazepine
carbutamide
carisoprodol
cartelolol
carvedilol
cefaclor
cefadroxil
cefixime
cefotaxime
ceftizoxime
cefuroxime
celiprolol
cefalexin
chlorambucil
chloramphenicol
chlordiazepoxide
chlormethiazole
chloroquine
chlorothiazide
chlorphenesin 
chlorpheniramine
chlorpromazine
chlorpropamide
chlorthalidone
chlorzoxazone
 
cimetidine
ciprofloxacin
cisapride
clemastine
clidinium
clinafloxacin
clindamycin
clindamycin
 
clomipramine 
clonazepam 
clonidine
clonidine
cloperastine 
clorgiline 
clotrimazole
cloxacillin
clozapine 
colchicine
xenical
lazabemide
tolcapone
 
trocade
tamiflu (hot)
tamiflu (LC-MS)
 
 
fleroxacin
bosentan
corticosterone
cotinine
coumarin
cromolyn 
cyclobenzapine 
cycloleucine 
cycloserine
cyproheptadine 
dapsone
desipramine
dexamethasone
dexbromopheniramine 
dextromethophan 
diazepam
diclofenac
dicloxacillin
dicyclomine 
digoxin
dihydroergotamine
diltiazem
dimenhydrinate
diphenhydramine 
dipyridamole
disopyramide
domperidone
doxapram
doxazosin
doxepin 
doxycycline
doxylamine 
droperidol 
drosperinone 
dyphylline
emetine 
enoxacin 
ephedrine
estrone 
17alpha-ethynylestradiol
 
ethionamide
etodolac 
etoperidone
etoposide
famotidine
felbamate
fenfluramine 
fexofenadine
finasteride 
flecainide 
fluconazole
fluorocytosine
flumazenil
 
flunisolide
fluorouracil
fluoxymesterone 
fluphenazine
flurazepam 
flubiprofen
flutamide
fluvastatin
foscarnet
furazolidone 
furosemide
gabapentin
galantamine 
ganciclovir
gemfibrozil
genaconazole
gentian violet 
gestodene 
glybenclamide
glyburide
glimepride
glipizide
glycyrrhetinic acid
haloperidol
hydralazine
hydrochlorothiazide
hydrocortisone
hydroflumethiazide
hydroflumethiazide
hydromorphine
hydroxyzine
ibuprofen
idarubicin
imipramine
indapamide 
indinavir
indomethacin
ipratropium
isobutamben 
isopropamide
isosorbide 
 
isoxicam
itraconazole
 
 
 
 
 
 
 
ketamine
ketamine
ketanserin
ketoconazole
ketoconazole
ketoprofen
ketorolac
labetalol
lamibudine
lansoprazole
levamisole 
levocabastine
levofloxacin 
levonorgestrel
levothyroxine 
liarozole 
lidocaine 
lincomycin
linogliride 
lisinopril
lomefloxacin
loperamide
loperamide 
loracarbef
lorazepam
lubeluzole
mannitol
mannitol
maprotiline
mebendazole
mecamylamine 
medroxyprogesterone 
mefenamic acid 
megestrol 
meperidine
meperidine
mephentermine 
metformin
methadone
methotrexate
a-methyldopa
methylprednisolone
methylsergide
metoclopamide
metolazone
metoprolol
metronidazole
mevastatin 
mianserin
miconazole 
midazolam
milameline 
milrinone 
 
minoxidil 
moclobemide
molsidomine
morphine 
nabumetone
N-acetylprocainamide
nadolol
naftopidil
nalbuphine
nalidixic acid 
nalmefene 
naloxone
naltrexone
naproxen
nebivolol
neostigmine
niacin 
nicotinic acid
niacinamide 
nicardipine 
niclosamide
niflumic acid 
nimodipine
nisoldipine 
nitrendipine
nitrofurantoin
nocodazole 
nomifensine
norethindrone
norfloxacin 
nortriptyline
nortriptyline
novobiocin
 
omeprazole
ondansetron
ornidazole
oxazepam
oxprenolol
oxprenolol
oxymetholone
oxyphenonium 
oxyquinoline
 
taxol
pantoprazole
papaverine
paroxypropione
 
 
 
 
 
PEG 4000
PEG 900
 
pentagastrin 
pentamidine 
pentazocine
pentoxifylline
perindopril
perphenazine
perphenazine
acetophenitidin
phenobarbital 
phensuximide 
phentermine 
phenylbutazone 
phenylephrine 
phenylethylmalonamide
phenytoin
physostigmine
picloram
pinacidil
pindolol
pipemidic acid
pirmenol p
piroxicam 
practolol
praziquantel 
prazosin
prednisolone
prednisone
pregabalin 
prenylamine
primaquine 
primidone
probenecid 
procainamide
procaine
prochlorperazine
procyclidine
progesterone
promazine
promethazine
propafenone
propafenone
propantheline 
propranolol
prucalopride 
pseudoephedrine
puromycin
pyrazinamide
pyridostigmine
pyridoxine 
pyrimethamine
quinacrine
quinapril 
quinidine
quinine
raclopride
ranitidine
ribavirin
riboflavin
riluzole 
risperidone
ritanserin 
ritodrine
ritonavir
rolipram
rolipram
JNJ 270201
JNJ 53308
sabeluzole
salicylic acid
salicylic acid 
SCH 56592
SCH 58235
antiestrogen
 
 
 
 
 
 
 
 
sotalol
sotalol
spironolactone 
stanozolol 
stavudine 
sulfadiazine 
sulfamerazine 
sulfamethazine 
sulfamethiazole 
sulfamethoxazole 
sulfaphenazole 
sulfapyridine
sulfasalazine
sulfinpyrazone 
sulfisomidine 
sulfisoxazole
sulindac
sulmazole 
sulpiride
sumatriptan
suprofen
tacrine
talinolol
temazepam 
terazosin
terbinafine 
terbutaline 
testosterone 
tetrahydrozoline
theobromine 
theophylline
thiabendazole 
thiamine
thiamylal 
thiopental
thioridazine
timolol
tinidazole 
tioconazole 
tiropramide
tisopurine
 
 
 
 
 
 
tocainide
tolazoline 
tolbutamide 
topiramate
tramadol
tranexamic acid
trazodone
triamcinolone
triamcinolone acetonide
triamterene
triazolam
trifluoperazine 
trimedoxime
trimethobenzamide
trimethoprim 
trimipramine
trioxsalen
triprolidine
troleandomycin
tulobuterol
 
valproic acid
valproic acid
venlafaxine
verapamil 
vidarabine
vinblastine
vinblastine
vinpocetine
warfarin
xamoterol 
yohimbine
zalcitabine
zalcitabine
zaleplon
zolpidem
zomepirac