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Friday
Mar042011

Human Hepatocyte data added

The human hepatocyte dataset was added.  This assay is a very comprehensive assay using 72 data points in order to most accurately determine the Km and Vmax values of the test compounds.  Although human hepatocytes are used by many laboratories, this comprehensive assay format is not one that many labs would routinely run or use in screening applications due to the great time and expense.  However, it generates very accurate data which is ideal for modeling applications.

A list of the compounds used in this assay are here.

A page with more information on the assay and dataset can be found here.

In the future we will be adding another human hepatocyte dataset using a simpler assay format which is more suitable for screening applications.  This data when compared to the more complete assay method will allow the comparison of the use of different assay protocols and the effect on calculated metabolic parameters.

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